The role of choline-phosphate cytidylyltransferase (CCTα) in cell metabolism and research progress in fish

Phospholipids are the primary components of cell membranes in eukaryotic organisms, and changes in their composition significantly affect cellular metabolic homeostasis. Phosphatidylcholine (PC) is primarily synthesized through the CDP-choline pathway, where choline cytidylyltransferase (CCT) acts as a key rate-limiting enzyme and a crucial factor in maintaining PC homeostasis. CCTα, a member of the nucleotide transferase superfamily, exhibits complex mechanisms to control the PC composition of membranes, which affects the physical properties of biological membranes and ultimately their biological functions, influencing various membrane-related cellular metabolic processes.Research on CCTα in fish is relatively scarce, primarily focusing on gene cloning and phenotypic roles in other cellular metabolic processes. Further in-depth exploration of its mechanisms in lipid metabolism, membrane biogenesis, and signal transduction is necessary.The role of CCT family proteins and their key member CCTα in cellular metabolism cannot be underestimated. Therefore, this article overviews of the research progress and specific functions of CCT family proteins and CCTα.