Abstract: In this paper,the optimum temperature,salinity and pH for juvenile growth of Ruditapes philippinarum were determined through the response surface methodology(RSM).The multivariate non-linear model was applied to study the interactions and optimization of the growth parameters for R.philippinarum which were explored by experiments.The results showed that:(1)there were significantly positive correlations between growth of shell-length and temperature and salinity within the range of experiment design.The relationship between growth of shell length and temperature and salinity and the growth of shell-length verged to positive correlation,and the calm grew better between pH 8 and 9;(2)there were no significant interactions between temperature,salinity and pH for the growth of juveniles.The multivariate non-linear model is as follows:Y=4.08+0.10A+0.18B+0.11C-0.055A²-0.13B²-0.12C²(R²=0.977 4),the optimum conditions for germination are as follows:temperature 29.65 ℃ and salinity 23.35‰ and pH=8.46±0.09.The experimental results indicated that the proposed model is reasonably accurate and can be used for describing and predicting the growth features ofR.philippinarum in different environmental factors.