Abstract: The samples of Penaeus chinensis and Penaeus vannamei were the third and the first generation respectively by selective breeding which have been artificially infected with WSSV. Random amplified polymorphic DNA (RAPD) technique was employed to analyze such samples that were still very healthy over tendayswith 220 primers. 99 distinctivegeneticmarkersaffiliatedwithdiseaseresistanttraitwereobtained,as analyzed , 18 were from P. chinensis disease resistant team with the molecular weight varying from 460 2305bp , and 81 were from P. vannamei disease resistant team with the molecular weight varying from 435 2287bp. Of 220 primers, 77 primersobtaineddistinctivegeneticmarkersfromthetwoteams,amongwhich 3, 2 and 1 distinctive fragments could be obtained from 4 , 13 and 61 primers , respectively.